Skip to main content
Search
Help
Retatrutide — 10mg vial; product photograph

Product photo · 10mg

Reports describe submitted samples for this amount and form.

Weight LossAppetite ControlMetabolic Health

Retatrutide

An experimental weekly injection being studied for weight loss, appetite and blood sugar.

Questions? Book a Free CallPeptify Analytics report (opens in a new tab)Mixing helper
Select strength
What does the amount mean?

10 mg is an amount of material. Read the label to see whether it means per vial, per tablet, or per package.

Read more
$90.00 CADsubtotal

1 vial · 10mg in each vial

Quantity
1

You can add this product to your cart. Checkout is temporarily unavailable.

Lab results
The research guide

Retatrutide, explained

An experimental weekly injection being studied for weight loss, appetite and blood sugar.

Published phase 2 and phase 3 trialsRead the sources

What it’s used for

Human study

Weight loss

Average weight loss was 25.0% over 80 weeks with 12 mg, versus 3.9% with placebo.

Human study

Blood-sugar control

Long-term blood sugar (HbA1c) fell 1.94 percentage points at 40 weeks with 12 mg, versus 0.81 with placebo.

Community reports

Less appetite

People report less hunger and easier appetite control.

Research topics

Other metabolic markers

Research also covers blood pressure, blood fats, liver fat and insulin sensitivity. Findings differ by outcome.

What to expect

  1. Weeks 1–4

    Appetite drops

  2. Following months

    Weight keeps changing

  3. Week 48

    24.2% average loss on 12 mg in the phase 2 trial

  4. Week 80

    25.0% average loss on 12 mg in the phase 3 trial

Side effects & safety

Side effects

  • Stomach and gut symptoms — the most common side effects, and more frequent at higher doses
  • Faster heart rate, rising with dose
  • Altered skin sensations

Stop and get help if

  • Severe abdominal pain, especially in the upper right side
  • Repeated vomiting or diarrhea
  • Signs of dehydration
  • Low blood sugar
  • Losing too much weight

What regs say

  • Not FDA-approved, and the FDA warns against unapproved retatrutide products.

Avoid or check first

  • Medullary thyroid cancer (MTC) or MEN2 risk — needs medical assessment first
  • Pregnant — needs medical assessment first
  • Already using semaglutide or tirzepatide — their effects overlap
  • Taking insulin — higher risk of low blood sugar

In sport

  • The reference considers it likely prohibited under S0 while unapproved. Sport Integrity Australia notes it is not named on the list; later approval could change the position.

How much people usually take

Common first dose

Once weekly · injectable

0.5–1 mg

How to mix and store it

How many units do I draw?

mL
Draw to10units0.1 mL
U-100 syringe volume reference, 30 units = 0.3 mL051015202530
Resulting concentration5 mg/mL
How to mix5 steps

  1. Wipe both tops

    Wash your hands, then swab both rubber vial tops with alcohol. Let them dry.

  2. Draw the water

    Use a new sterile syringe to draw the water volume selected in the calculator.

  3. Run it down the wall

    Introduce the water slowly down the inside glass wall, rather than directly onto the powder.

  4. Swirl, don’t shake

    Gently swirl or roll the vial. Allow time for the powder to dissolve.

  5. Label the vial

    Write the preparation date and the amount and final volume on the vial label.

Injecting under the skinWhere, rotating sites, which syringe

Where

Subcutaneous injections go into the fatty layer beneath the skin. Common sites include the abdomen, outer thigh and upper arm. Keep at least 5 cm from the navel and avoid bruised, irritated or damaged skin.

Rotate sites

Change the spot each time. Clean the skin and let it dry.

Single-use equipment

Use a new sterile needle and syringe each time. Place used needles in a sharps container.

Storage

Fridge · 28 days

Refrigerated at 2–8°C. The reported 28-day period has not been tested for every vial.

Dry powder

Room temperature.

Combining it with others

Don’t combine

  • Survodutide

    Similar appetite-hormone effects can add to nausea and dehydration.

  • Mazdutide

    Similar appetite-hormone effects can add to nausea and dehydration.

  • Orforglipron

    Similar appetite-hormone effects can add to nausea and dehydration.

Use caution

  • Insulin or sulfonylureas

    Both lower blood sugar, which may make it fall too low.

  • Oral medicines

    Slower stomach emptying can change how pills are absorbed.

  • IGF-1 LR3

    Both lower blood sugar, increasing concern about it falling too low.

  • MK-677

    Increased hunger and blood sugar work against the appetite-hormone effects.

  • GHRP-6

    One increases hunger while the other reduces it.

  • Tesofensine

    Concerns about the heart, blood pressure and eating too little may add up.

  • Adipotide

    Kidney injury seen in animals may add to kidney concerns linked to dehydration.

  • Melanotan I

    Nausea may get worse.

  • Melanotan II

    Nausea may get worse.

  • PT-141

    Nausea may get worse.

  • Cagrilintide

    Slower stomach emptying and reduced appetite can add to nausea.

  • Eloralintide

    Slower stomach emptying and reduced appetite can add to nausea.

What the research says

Three hormone targets

Retatrutide activates GLP-1, GIP and glucagon receptors.

Human study

Blood-sugar study

TRANSCEND-T2D-1 followed 537 adults with type 2 diabetes for 40 weeks. Long-term blood sugar (HbA1c) fell 1.69–1.94 percentage points across retatrutide groups, versus 0.81 with placebo.

What studies found

Phase 2 weight study

Human study · 338 adults · 48 weeks

The trial followed 338 adults for 48 weeks. At week 24, average weight loss ranged from 7.2% to 17.5%, versus 1.6% with placebo. At week 48, weight changes ranged from −8.7% to −24.2%, versus −2.1%. Stomach symptoms and heart-rate changes were also recorded.

TRIUMPH-1

Human study · 2,339 adults · 80 weeks

In 2,339 adults with obesity and no diabetes, average weight changes at 80 weeks were −17.6%, −23.7% and −25.0% across the three groups, versus −3.9% with placebo. Stomach symptoms were the most common side effects.

How long it stays in your body

Half-life is the time it takes for the amount in the body to fall by half. It does not tell you how long effects last.

Half-life≈ 6 days
Mostly cleared30 daysAbout 97% gone after five half-lives
Half-lifeUnder-the-skin injection in the study
50%Estimated amount left
6 daysAfter one dose
Illustrative Retatrutide half-life model: 50% remaining after 6 days. Normalized single exponential decline, not measured individual blood levels.0%50%100%0 d6 d12 d18 d24 d30 d

Drag to see how much is left over time.

What it’s made of

Length39-residue backbone
Molecular weight≈4731 Da (calculated from reference formula; excludes counterions)
FormulaC221H342N46O68
CAS reference2381089-83-2

Sequence 39 · N → C

  1. Tyr
  2. Aib
  3. Gln
  4. Gly
  5. Thr
  6. Phe
  7. Thr
  8. Ser
  9. Asp
  10. Tyr
  11. Ser
  12. Ile
  13. alphaMeLeu
  14. Leu
  15. Asp
  16. Lys
  17. Lys
  18. Ala
  19. Gln
  20. Aib
  21. Ala
  22. Phe
  23. Ile
  24. Glu
  25. Tyr
  26. Leu
  27. Leu
  28. Glu
  29. Gly
  30. Gly
  31. Pro
  32. Ser
  33. Ser
  34. Gly
  35. Ala
  36. Pro
  37. Pro
  38. Pro
  39. Ser

Backbone runs from N to C terminus. Aib is alpha-aminoisobutyric acid; alphaMeLeu is alpha-methyl-L-leucine. Lys17 carries a fatty-diacid moiety through a linker; the C terminus is amidated. The token sequence alone does not encode the complete acylated structure.

Molecular notes

Retatrutide / LY3437943. WHO supplies the modified reference molecule’s formula. Using CIAAW abridged atomic weights, 221×12.011 + 342×1.0080 + 46×14.007 + 68×15.999 = 4731.421, rounded to approximately 4731 Da. This average formula mass excludes counterions and is not a measured monoisotopic mass or a Monroe vial assay.

Lab results

10mg · 2 linked reports

Purity · sample result
99.718% / 99.805% / 99.563%
Amount found · Retatrutide
Sample 1: 11.03 mgSample 2: 11.03 mgSample 3: 10.92 mg

Separate sample results, in report order.

These are submitted-sample results, separate from general research or popularity ratings. Report presentation: Peptify Analytics. Source laboratory: Janoshik Analytical. The connection to the batch you would receive is not confirmed here.

Videos worth watching

Research conversations, with their original context.

Dr. Alex TatemRetatrutide Dosing Explained (Doctor Breaks Down the Data) (opens in a new tab)This Is Not Covered - Dr. Ashley FroeseRetatrutide Side Effects - Dr Reveals the BAD, The UGLY (opens in a new tab)Dr. Jones, DCDoctor Explains How Retatrutide Can Potentially Be Dangerous If Done Wrong (WATCH BEFORE TAKING) (opens in a new tab)Ryan Sims | Optimal Health ProjectI Lost 35 lbs on Retatrutide — The Good, Bad & One Big Mistake (opens in a new tab)Kait Malthaner (BSc Nutrition & Exercise)Why I quit retatrutide (even though it was working) (opens in a new tab)

Product details

Form
Vial
Amount
10mg

Sources & further reading

Follow each reference to its original publication or documentation.

Questions

What does 10mg mean?

It describes an amount of material in the unit stated on the label. It does not describe liquid volume, a dose, or how to prepare the product.

Read more about amounts
Does purity mean it is sterile?

No. Purity and sterility require different tests. An endotoxin result also does not establish sterility.

About testing
Can I calculate concentration?

You need a mass in mg and either a final volume or a target concentration. IU and blends require separate, verified information.

Use the mixing helper for this amount ↑
How can I get help with an order?

Open your order details to check its current status. Shipping and support information are available below.

Contact us

More to explore

Shop all