Adipotide
What it’s used for
Lab & animal research
Adipotide (prohibitin-TP01) is an experimental peptide designed to damage the blood vessels that feed white fat. People are interested in it for fat and weight loss. Obese monkeys lost weight and fat on it but showed kidney injury signals, and there's no human evidence that it works or is safe.
- Fat & weight loss Obese monkeys lost weight and white fat with daily injections over 28 days.
- Insulin response Insulin responses improved in the same monkey research.
What to expect
- Weeks 1–2
Changes in waist size (abdominal circumference)
- Weeks 2–4
Fat and weight changes
- After stopping
Possible rebound
Side effects & safety
Side effects
- Kidney injury in monkeys: reversible proximal-tubule damage, with creatinine and electrolyte changes
Stop and get help if
- Passing less urine, or kidney or electrolyte blood tests that stay abnormal
- Severe injection-site or whole-body reactions, or any unexpected toxicity
Which symptoms mean call 911 or see a doctor
Avoid or check first if
- Pregnant or breastfeeding — safety hasn't been studied
- Taking kidney-straining drugs such as NSAIDs or aminoglycoside antibiotics — risk of added kidney injury
In sport
Likely banned at all times. An experimental fat-targeting peptide whose only trial was stopped at phase 1, so it’s an unapproved S0 substance.
Which peptides are banned in sport
How much people take
- Dose‑finding (research) Once daily · under the skin (escalating tiers) · 28 days 0.10–0.75 mg/kg
Similar doses appear in 3 other sources
How to mix and store it
How many units do I draw?
Open the full calculator
How to mix 5 steps with bacteriostatic water · vial check
How to mix
- 1 Wipe both tops Wash your hands, then swab the rubber tops of the peptide vial and the water vial with alcohol. Let them dry.
- 2 Draw the water Use bacteriostatic (BAC) water — sterile water with a preservative, sold for mixing peptides . With a new sterile syringe, draw the amount you entered in the calculator. A 1 mL syringe filled twice is 2 mL.
- 3 Run it down the wall Push the needle into the peptide vial at an angle and let the liquid trickle down the glass, not onto the powder.
- 4 Swirl, don’t shake Gently swirl or roll the vial until the liquid is completely clear. Give it a few minutes if needed.
- 5 Label the vial Write the date and what you mixed (for example 5 mg + 2 mL) on the vial.
This is general practice. If your product came with its own diluent or instructions, follow those. Not sure what to buy? See the supplies checklist .
Is my vial OK?
Good signs
- Intact freeze-dried powder
- Clear solution
Can be normal
- Minor clumping
Don’t use if
- Collapsed/moist powder
- Cloudiness/precipitate
Injecting under the skin Where, rotating sites, which syringe
- Where: belly (at least 2 in / 5 cm from the navel), front of the thigh, or back of the upper arm.
- Rotate sites each time and skip bruised, scarred or sore skin.
- Syringe: most people use a U-100 insulin syringe with a short, thin needle (29–31 gauge, 8 mm or shorter).
- How: wipe with alcohol and let it dry, pinch the skin, go in at 45–90°, push slowly. Use each syringe once.
General practice for under-the-skin injections, not specific to Adipotide.
The full guide: how to inject safely
Storage
Fridge · 2–8°C How long a mixed vial stays good is unknown
Combining it with others
AI assessment Based on how each compound works, not on studies of the combination. How we assess
Use caution 8
- Semaglutide Adipotide harmed kidneys in animal studies. Vomiting and dehydration from GLP-1 drugs add kidney strain.
- Tirzepatide Adipotide harmed kidneys in animal studies. Vomiting and dehydration from GLP-1 drugs add kidney strain.
- Retatrutide Adipotide harmed kidneys in animal studies. Vomiting and dehydration from GLP-1 drugs add kidney strain.
- Survodutide Adipotide harmed kidneys in animal studies. Vomiting and dehydration from GLP-1 drugs add kidney strain.
- Mazdutide Adipotide harmed kidneys in animal studies. Vomiting and dehydration from GLP-1 drugs add kidney strain.
- Orforglipron Adipotide harmed kidneys in animal studies. Vomiting and dehydration from GLP-1 drugs add kidney strain.
- PNC-27 Both work by killing targeted cells, with no human safety data. Too many unknowns together.
- FOXO4-DRI Both work by killing targeted cells, with no human safety data. Too many unknowns together.
Can be combined 2
What the research says
Mostly animal studies
- Human benefit and a safe dose are unknown; results come from monkeys and mice.
- A first-in-human phase 1 trial was registered (NCT01262664), but human efficacy remains unconfirmed.
- Product identity, purity and formulation can't be confirmed from published research.
What studies found
- Newer research uses a different analogue The 2025 mixed-chirality study evaluated a modified prohibitin-targeting compound in obese mice. It does not verify adipotide efficacy, preparation or dosing in people.
- Primate weight loss with renal effects Obese monkeys lost weight and white adipose tissue; renal proximal-tubule function changed. The study does not establish human safety.
Half-life and molecule details haven’t been verified for this compound.
Doses in animal and lab studies 2
Doses used in animal or cell studies. They don’t translate directly to people.
- Fixed-dose primate experiment 0.43 mg/kg · Daily · SubQ
- Primate research replication 0.43 mg/kg · Once daily · SubQ
Sources
Sources 15
How this page was made
How it may work: A vascular-targeting sequence delivers a mitochondrial-disrupting motif, killing targeted endothelial cells.
Other names: Adipotide (Prohibitin‑TP01)
Preparation in studies: No universal bacteriostatic-water volume or validated preparation method is established for this entry.
Research last checked: Oct 12, 2026 (a targeted search, not a full review).
Community doses, how long people take it, timing and storage are compiled with AI from public peptide guides, clinics and forums, cross-checked against other sources where we could, and rewritten in plain language. “Combining it with others” is an AI assessment of how the compounds work. Study notes are written from each paper’s abstract where one exists. How we source
Original source guide